#Database_OTU Count Abundance Taxonomy 264055 48 0.00123558 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_264055 264844 7 0.000180189 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_264844 1047041 2 5.14825e-05 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Corynebacteriaceae; Corynebacterium; Unclassified; otu_1047041 321584 1552 0.0799009 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Unclassified; otu_321584 275895 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_275895 1144585 2 0.000102965 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Microbacteriaceae; Salinibacterium; Unclassified; otu_1144585 337494 642 0.0165259 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_337494 322927 4 0.00020593 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Unclassified; otu_322927 624310 2 0.000102965 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Sanguibacteraceae; Sanguibacter; Unclassified; otu_624310 1705765 37 0.00190485 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Oxalobacteraceae; Massilia; sp._UFLA04_317; otu_1705765 197600 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_197600 523099 24 0.000617791 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_523099 4028110 10 0.000128706 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; Unclassified; otu_4028110 181597 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_181597 299171 7 0.000360378 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_299171 30062 5 0.000257413 Bacteria; Firmicutes; Clostridia; Clostridiales; Tissierellaceae; Anaerococcus; Unclassified; otu_30062 270391 1 5.14825e-05 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_270391 194490 1 5.14825e-05 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_194490 175367 4 6.86434e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia; Unclassified; otu_175367 267175 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_267175 161993 13 0.000669273 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_161993 1084865 825 0.0424731 Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus; warneri; otu_1084865 162539 224 0.0115321 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_162539 708851 1 5.14825e-05 Bacteria; Cyanobacteria; Chloroplast; Cryptophyta; Unclassified; Unclassified; Unclassified; otu_708851 494906 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Tissierellaceae; Peptoniphilus; Unclassified; otu_494906 3991164 1 7.35465e-06 Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Anoxybacillus; kestanbolensis; otu_3991164 3013444 648 0.0333607 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Rikenellaceae_Group; Unclassified; otu_3013444 190242 48 0.00247116 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_190242 153978 1 5.14825e-05 Bacteria; Cyanobacteria; Chloroplast; Streptophyta; Unclassified; Unclassified; Unclassified; otu_153978 855538 2 0.000102965 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Propionibacteriaceae; Propionibacterium; acnes; otu_855538 1111512 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_1111512 1071316 1 5.14825e-05 Bacteria; Bacteroidetes; Sphingobacteria; Sphingobacteriales; Chitinophagaceae; Flavisolibacter; Unclassified; otu_1071316 4482598 27 0.000278006 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; Unclassified; otu_4482598 275321 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_275321 4404405 1 8.58042e-06 Bacteria; Firmicutes; Bacilli; Lactobacillales; Carnobacteriaceae; Desemzia; Unclassified; otu_4404405 235262 1 5.14825e-05 Bacteria; Actinobacteria; Actinobacteria; Bifidobacteriales; Bifidobacteriaceae; Bifidobacterium; adolescentis; otu_235262 264240 790 0.0406712 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_264240 808810 1 5.14825e-05 Bacteria; Cyanobacteria; Chloroplast; Stramenopiles; Unclassified; Unclassified; Unclassified; otu_808810 934488 3 0.000154448 Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus; Unclassified; otu_934488 274795 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_274795 290210 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_290210 2270571 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Sphingomonas; Unclassified; otu_2270571 532569 41 0.00211078 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; lwoffii; otu_532569 208929 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Oxalobacteraceae; Janthinobacterium; Unclassified; otu_208929 196428 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_196428 167509 592 0.0304777 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Oscillospira; Unclassified; otu_167509 178558 3 0.000154448 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella; Unclassified; otu_178558 936354 1 1.28706e-05 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Moraxellaceae_Group; Unclassified; otu_936354 310748 13 0.000669273 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_310748 313037 3 7.72238e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_313037 264325 326 0.0167833 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_264325 45591 1 5.14825e-05 Bacteria; Acidobacteria; Acidobacteria; Acidobacteriales; Acidobacteriaceae; Granulicella; Unclassified; otu_45591 609589 3 0.000154448 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_609589 261256 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_261256 144048 1 5.14825e-05 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; Unclassified; otu_144048 1112121 3454 0.177821 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_1112121 4311417 1 5.14825e-05 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Actinomycetaceae; Actinomyces; viscosus_naeslundii_oris; otu_4311417 850108 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales; Caulobacteraceae; Brevundimonas; diminuta; otu_850108 292807 6 0.000308895 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_292807 566391 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_566391 199532 17 0.000875203 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_199532 4420570 1 5.14825e-05 Bacteria; Cyanobacteria; Chloroplast; Streptophyta; Streptophyta_Group; Streptophyta_Group; nbw608h09c1; otu_4420570 267373 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_267373 174337 1 1.71608e-05 Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales; Verrucomicrobiaceae; Akkermansia; muciniphila; otu_174337 445733 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Erythrobacteraceae; Altererythrobacter; Unclassified; otu_445733 337784 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Mogibacteriaceae; Mogibacteriaceae_Group; Unclassified; otu_337784 815715 11 0.000566308 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; lwoffii; otu_815715 358007 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_358007 316888 1 1.02965e-05 Bacteria; Firmicutes; Bacilli; Lactobacillales; Carnobacteriaceae; Desemzia; Unclassified; otu_316888 275470 3 0.000154448 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_275470 336614 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia; Unclassified; otu_336614 263933 3531 0.181785 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_263933 143704 5 0.000128706 Bacteria; Proteobacteria; Gammaproteobacteria; Chromatiales; Chromatiaceae; Rheinheimera; Unclassified; otu_143704 805093 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Oxalobacteraceae; Massilia; Unclassified; otu_805093 322506 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Comamonadaceae_Group; Unclassified; otu_322506 191753 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_191753 4426763 2 0.000102965 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Comamonadaceae_Group; Unclassified; otu_4426763 216356 12 0.000617791 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_216356 889549 1 5.14825e-05 Bacteria; Bacteroidetes; Sphingobacteria; Sphingobacteriales; Chitinophagaceae; Chitinophagaceae_Group; Unclassified; otu_889549 705337 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_705337 840376 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Eubacterium; Unclassified; otu_840376 258169 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_258169 2189140 1 5.14825e-05 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae; Bacteroides; Unclassified; otu_2189140 349482 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_349482 1790396 1 1.02965e-05 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; johnsonii; otu_1790396 4449524 209 0.0107599 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella; Unclassified; otu_4449524 169398 8 0.00041186 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_169398 879040 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Kaistobacter; Unclassified; otu_879040 628218 6 0.000308895 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_628218 189076 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Alcaligenaceae; Sutterella; Unclassified; otu_189076 3138798 1 5.14825e-05 Bacteria; Firmicutes; Negativicutes; Selenomonadales; Veillonellaceae; Phascolarctobacterium; Unclassified; otu_3138798 170950 6 0.000308895 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_170950 275628 28 0.000720756 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_275628 261519 2177 0.112077 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_261519 345994 7 0.000360378 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_345994 327432 6 0.000308895 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Oxalobacteraceae; Massilia; Unclassified; otu_327432 948180 1 5.14825e-05 Bacteria; Actinobacteria; Actinobacteria; Micrococcales; Microbacteriaceae; Amnibacterium; Unclassified; otu_948180 189147 5 0.000257413 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcus; Unclassified; otu_189147 564140 1 1.02965e-05 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Porphyromonadaceae; Parabacteroides; distasonis; otu_564140 341749 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_341749 183864 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Faecalibacterium; prausnitzii; otu_183864 276172 4 0.00020593 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Rikenellaceae; Alistipes; Unclassified; otu_276172 272646 5 0.000257413 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_272646 194962 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia; Unclassified; otu_194962 692510 1 5.14825e-05 Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Bdellovibrionaceae; Bdellovibrio; Unclassified; otu_692510 161677 18 0.000231671 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Moraxellaceae; Acinetobacter; schindleri; otu_161677 1108599 353 0.00908667 Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales; Desulfovibrionaceae; Desulfovibrio; Unclassified; otu_1108599 451449 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Tissierellaceae; Anaerococcus; Unclassified; otu_451449 3574065 5 0.000257413 Bacteria; Cyanobacteria; Chloroplast; Streptophyta; Unclassified; Unclassified; Unclassified; otu_3574065 244234 2 0.000102965 Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales; Aeromonadaceae; Tolumonas; Unclassified; otu_244234 4336940 7 0.000180189 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_4336940 4021961 1 5.14825e-05 Bacteria; GN02; BD1_5; Unclassified; Unclassified; Unclassified; Unclassified; otu_4021961 813418 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales; Sphingomonadaceae; Sphingopyxis; Unclassified; otu_813418 258411 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Blautia; Unclassified; otu_258411 261574 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_261574 811644 4 0.00020593 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Corynebacteriaceae; Corynebacterium; Unclassified; otu_811644 183163 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Roseburia; Unclassified; otu_183163 229452 9 0.000463343 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_229452 262927 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_262927 1066814 1 5.14825e-05 Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Prevotellaceae; Prevotella; Unclassified; otu_1066814 837424 1 5.14825e-05 Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales; Hyphomonadaceae; Hirschia; Unclassified; otu_837424 83475 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Polaromonas; Unclassified; otu_83475 495084 491 0.0252779 Bacteria; Firmicutes; Clostridia; Clostridiales; Tissierellaceae; Anaerococcus; Unclassified; otu_495084 661055 1454 0.0748556 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_661055 1903534 1 5.14825e-05 Bacteria; Actinobacteria; Coriobacteria; Coriobacteriales; Coriobacteriaceae; Atopobium; Unclassified; otu_1903534 4306036 200 0.0102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Ruminococcaceae; Ruminococcaceae_Group; Unclassified; otu_4306036 4458997 2 0.000102965 Bacteria; Proteobacteria; Betaproteobacteria; Procabacteriales; Procabacteriaceae; Procabacteriaceae_Group; Unclassified; otu_4458997 3176547 231 0.0118925 Bacteria; Firmicutes; Clostridia; Clostridiales; Unclassified; Unclassified; Unclassified; otu_3176547 268257 7 0.000360378 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_268257 1712416 1 1.71608e-05 Bacteria; Firmicutes; Bacilli; Gemellales; Gemellaceae; Gemella; haemolysans; otu_1712416 143958 2 0.000102965 Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas; sp._B_2051; otu_143958 303652 2 0.000102965 Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus; Unclassified; otu_303652 277574 2 0.000102965 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_277574 184484 1 5.14825e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_184484 254888 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Pelomonas; MP104-0927-b59; otu_254888 368097 1 5.14825e-05 Bacteria; Actinobacteria; Actinobacteria; Actinomycetales; Micrococcaceae; Kocuria; Unclassified; otu_368097 837473 1150 0.0592049 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_837473 267110 607 0.0312499 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_267110 275873 1 2.57413e-05 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_275873 262994 8 0.00020593 Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae; Lachnospiraceae_Group; Unclassified; otu_262994 255518 1 5.14825e-05 Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Comamonadaceae; Tepidimonas; Unclassified; otu_255518 98258 1 5.14825e-05 Bacteria; Cyanobacteria; 4C0d_2; MLE1_12; Unclassified; Unclassified; Unclassified; otu_98258