Project Overview

P_SRP341393

Electronic_Cigarette_Use_Promotes_a_Unique_Periodontal_Microbiome

Visibility: Public
Publication: Electronic_cigarettes_(e-cigs)_have_become_prevalent_as_an_alternative_to_conventional_cigarette_smoking,particularly_in_youth._E-cig_aerosols_contain_unique_chemicals_which_alter_the_oral_microbiome_and_promote_dysbiosis_in_ways_we_are_just_beginning_to_investigate._We_conducted_a_6-month_longitudinal_study_involving_84_subjects_who_were_either_e-cig_users,conventional_smokers,or_nonsmokers._Periodontal_condition,cytokine_levels,and_subgingival_microbial_community_composition_were_assessed,with_periodontal,clinical,and_cytokine_measures_reflecting_cohort_habit_and_positively_correlating_with_pathogenic_taxa_(e.g.,Treponema,Saccharibacteria,a_n_d_Porphyromonas)._a-Diversity_increased_similarly_across_cohorts_longitudinally,yet_each_cohort_maintained_a_unique_microbiome._The_e-cig_microbiome_shared_many_characteristics_with_the_microbiome_of_conventional_smokers_and_some_with_nonsmokers,yet_it_maintained_a_unique_subgingival_microbial_community_enriched_in_Fusobacterium_and_Bacteroidales_(G-2)._Our_data_suggest_that_e-cig_use_promotes_a_unique_periodontal_microbiome,existing_as_a_stable_heterogeneous_state_between_those_of_conventional_smokers_and_nonsmokers_and_presenting_unique_oral_health_challenges. Link
 Journal: mBio
Source: NA
Sample Number: 88

Samples in this project
  

SampleID Type Habitat Year Sequence type MNS1 MAS2
S_SRP341393.SRR16338604 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338606 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338607 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338613 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338614 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338616 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338617 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338619 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338620 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338622 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338623 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338624 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338625 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338629 Oral Oral 2017 16S_V3-V4 - -
S_SRP341393.SRR16338631 Oral Oral 2018 16S_V3-V4 - -
S_SRP341393.SRR16338632 Oral Oral 2018 16S_V3-V4 - -
S_SRP341393.SRR16338634 Oral Oral 2018 16S_V3-V4 - -
S_SRP341393.SRR16338636 Oral Oral 2016 16S_V3-V4 - -
S_SRP341393.SRR16338637 Oral Oral 2018 16S_V3-V4 - -
S_SRP341393.SRR16338638 Oral Oral 2018 16S_V3-V4 - -

1MNS (Microbiome Novelty Score): < 0.12: Non-novel; 0.12-0.2: Novel; > 0.2: Very novel; -: NA for samples before 2010

2MAS (Microbiome Attention Score): < 10: Low-attention; ≥ 10: High-attention; -: NA for samples before 2010